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How Long-Term Depression Affects the Body and Mind

May 1, 2025

Depression is more than just feeling sad. It’s a serious mental health condition that affects millions of people across the United States. It impacts not only the mind, but also the body in profound and sometimes surprising ways. When depression becomes long-term, the effects can ripple through every part of a person’s life, contributing to physical health problems, emotional instability, and diminished quality of life.

Understanding how long-term depression manifests is essential for getting the right treatment and support. Below, we explore the mental and physical symptoms of depression, its possible causes, and how it can affect your overall health.

What Is Long-Term Depression?

Long-term depression, also referred to as major depressive disorder or chronic depression, involves persistent feelings of sadness, hopelessness, and fatigue that can last for months or years. Many people may not realize they’re depressed until symptoms interfere with daily life.

According to the National Institute of Mental Health, depression is one of the most common mental health disorders in the United States and affects people of all ages. It can be especially impactful in older adults who may already be dealing with chronic illness, isolation, or grief.

Mental and Emotional Impact

The emotional toll of depression can be overwhelming. Common mental symptoms of depression include:

· Persistent sadness or anxiety

· Feelings of hopelessness or worthlessness

· Loss of interest in hobbies or activities once enjoyed

· Difficulty concentrating or making decisions

· Suicidal thoughts or frequent thoughts of death

When left untreated, these symptoms can intensify and lead to serious consequences for mental well-being.

Physical Symptoms of Depression

While the emotional symptoms are often most recognized, the physical symptoms of depression are just as real and often harder to identify. These may include:

· Chronic fatigue or low energy

· Insomnia or excessive sleeping

· Changes in appetite or weight gain

· Muscle aches and chronic pain

· Gastrointestinal issues

· Lowered immune system function

In many cases, physical complaints are what lead someone to seek medical help, without realizing depression may be the underlying cause.

Long-Term Health Risks

Over time, long-term depression can increase the risk of developing serious health problems, especially if it’s not properly diagnosed or treated. Common complications include:

1. Heart Disease

Chronic stress and depression have been linked to increased inflammation and elevated blood pressure, both of which are risk factors for heart disease. Depression may also lead to poor lifestyle habits, such as smoking or lack of exercise, which can worsen heart health.

2. Type 2 Diabetes

Depression may influence the development of type 2 diabetes by affecting how the body regulates insulin and through lifestyle factors like poor diet, weight gain, and inactivity.

3. Weakened Immune System

Ongoing depression can suppress immune function, making it harder for the body to fight off illness and recover from injury.

4. Chronic Pain Conditions

There is a strong connection between depression and conditions like fibromyalgia, arthritis, and back pain. People with long-term depression often report higher levels of chronic pain, which can become a cycle of discomfort and emotional distress.

Causes and Risk Factors

There isn’t a single cause of depression. Often, it’s a combination of biological, psychological, and environmental factors. Some common risk factors include:

· Family history of depression or mental illness

· Major life changes, trauma, grief, or prolonged stress

· Medical conditions like heart disease or cancer

· Substance abuse

· Social isolation or lack of support

Understanding these risk factors can be helpful in diagnosing depression early and accurately.

Why Diagnosing Depression Is Challenging

Depression doesn’t always look the same in everyone. Some people may feel persistently sad, while others may become irritable or physically ill. Many individuals downplay their symptoms or assume they’ll simply “snap out of it.”

However, long-term depression often requires professional intervention. A comprehensive diagnosis typically involves a clinical evaluation, discussion of symptoms, and sometimes screening tools or questionnaires. At Denver Wellness Associates, we offer in-person and telehealth services designed to support accurate diagnosis and personalized treatment.

Seeking Help Makes a Difference

The good news? Depression is highly treatable.

A combination of approaches such as therapy, medication, lifestyle changes, and support groups can make a meaningful difference. For many, learning coping strategies and receiving compassionate care helps restore both mental and physical well-being.

If you or someone you know is struggling, don’t wait to get help. Especially when symptoms persist, worsen, or begin affecting your health, early intervention is key.

Final Thoughts

Depression is more than a low mood, it’s a medical condition with wide-reaching effects. Whether you’re noticing chronic pain, weight gain, or a loss of interest in the things you love, your mind and body may be telling you that something’s off.

At Denver Wellness Associates, we understand how complex and personal depression can be. Our team is here to help you navigate your journey with compassion and clinical expertise, whether you’re struggling yourself or supporting a loved one.

Remember: You don’t have to carry this alone.

Need support? Contact Denver Wellness Associates to schedule an appointment or learn more about our therapy and psychiatry services for long-term depression and related health concerns.

Filed Under: Depression

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At Denver Wellness Associates, our psychiatric providers offer comprehensive mental health services including TMS, Psychiatric Treatment, Genetic Testing, Spravato & Ketamine-Assisted Therapy, ADHD Testing, and Therapy.